Tuesday, February 26, 2013

Recent Psychiatric New Headlines of Relevance to This Blog

All the News That’s S**t  to Print

Keeping up with all of the new developments in psychiatry from multiple journals, as well as all of related recent sociopolitical events, has been made much more simple of late thanks to medical daily e-mail news services from Medscape (from WebMD), the American Psychiatric Association, and various other psychiatric publications. 

Often the headlines are more telling than the actual stories. Some of the headlines seem to blindly accept misleading conclusions of the type about which I blog frequently – although the publications do use the word “may” a lot so as not to imply that any conclusion is actually proven. Other stories clearly contradict these same very conclusions.

Here are some of the recent stories that touch on issues discussed and debated in this blog, organized by topic.  My comments are in italics.

Bipolar Disorder, My A**.

10/2/12.  Study: Screening For BD May Reveal Undiagnosed Anxiety Disorder. MedWire (10/2, Grasmo) reports, "Patients who receive a false-positive diagnosis during screening tests for bipolar disorder [BD] are likely to have an undiagnosed anxiety disorder," according to a study published in Dec. 1 issue of the Journal of Affective Disorders. For the study, "1534 patients attending the Black Dog Institute Depression Clinic completed the Mood Swings Questionnaire (MSQ)-46 and 852 also completed the Mood Disorders Questionnaire (MDQ)." Notably, "46% of MSQ-assigned false positives and 63% of MDQ-assigned false positives in the unipolar non-melancholic group had comorbid anxiety conditions."

Patients with obvious anxiety disorders who have been misdiagnosed as having bipolar disorder are beginning to show up in my office with alarming frequency, often having been placed on a whole stew of inappropriate medication. Also, the MDQ is one of those totally invalid symptom checklists.

2/15/2013.  Mania Symptoms Appear Similar For Kids, Teens. Medwire (2/15, Piper) reports, "The nature of mania symptoms appears to be similar in young people with bipolar disorder, irrespective of whether they occur in childhood or adolescence," according to a study published in the March issue of the Journal of Affective Disorders. The study authors did find, however, that "the only exception was the emergence of psychotic symptoms, including hallucinations and delusions, in adolescents with adolescent-onset of symptoms, but not in children with child-onset symptoms." The study also found that "mania symptomatology that was similar across 163 children with child-onset of symptoms (before 12 years of age), 94 adolescents with child-onset of symptoms, and 90 adolescents with adolescent-onset of symptoms (after 12 years of age) was characterized by 'activated/pleasure seeking' and 'labile and disorganized' behaviors."

Question: Isn't it a surprising coincidence that the one symptom that actually might establish a link between some active children and bipolar disorder – psychosis – is almost never found in children, while on the other hand, symptoms suggestive of acting out are prominent.  Answer:  No. 

Shoddy Psychiatric Care Practices 

12/13/12.  Older Americans Concerned About Mental Health Care They Receive, Survey Finds.  A survey released today of Americans aged 65 and older finds troubling gaps in the care these individuals receive for mental illnesses. Among the key findings are that 46% of seniors who are in treatment for a mental health problem said their provider did not follow up with them within a few weeks of their beginning treatment to see how they were doing and that 38% said that their provider had not discussed the possible side effects of prescribed medications. The findings are from a survey of more than 1,300 older adults conducted in November and published in a report by the John A. Hartford Foundation, which describes itself as "a committed champion of health care training, research, and service-system innovations that will ensure the well-being and vitality of older adults."  In addition, 33% of respondents said their provider failed to discuss treatment options, 40% said there was no discussion of how long treatment might last, and 34% said they were not told what steps to take if their condition seemed to worsen. The survey also asked survey participants about their knowledge of depression. Judging from the responses, considerably more education is needed, particularly regarding the links between depression and overall health. For example, only 34% were aware that depression is associated with a substantial risk of heart disease, a link that has been described in multiple studies and reported extensively.

The findings highlighted in red are indeed disturbing.  If your psychiatrist fails to do some or all of them, please run away as fast as you can, and find another psychiatrist immediately.

Cuts in Mental Health Services

 It’s amazing how some people keep wondering why there are so many more mentally ill people homeless on the street, and/or why they are crowding our jails.

12/26/12.  Studies: Number Of US Inpatient Psychiatric Beds Shrinking. The Denver Post (12/23, O'Connor) reported that a report published last February in the journal Emergency Physicians Monthly found a 60% decrease in the number of psychiatric beds available for inpatients in the US between the years 1970 and 2002. Bed counts at hospitals run by counties and states plummeted by 90%, the article said. A 2008 study [pdf] conducted by the American College of Emergency Physicians revealed that Colorado has only 11.8 inpatient psychiatric beds per 100,000 persons, which appears to be one of the worst rates in the US.

12/27/12.  Report: $4.35B Cut From State Mental Health Services Since 2009. The Huffington Post (12/27, Horowitz) reports, "In the past three years, $4.35 billion for services has been cut from state budgets across the country, according to a report by the National Association of State Mental Health Program Directors Research Institute." At the same time that "states are slashing funding for treatment, private care is getting harder to obtain. Mental health advocates say that the number of [practitioners] nationwide has decreased in recent years."

1/23/13. More Psychiatric Patients Forced To Wait In EDs Due To Cutbacks In Inpatient Beds. The Washington Post (1/23, Khazan) reports on an "increasingly common" problem for psychiatric patients nationwide, where mental health patients are "boarded" in hospital emergency departments "in part because of cutbacks in inpatient hospital beds." The Post explains, "As states trimmed their budgets in the economic downturn, resources for mental health patients were among the casualties." The piece notes, "For many patients suffering from psychiatric crises, this translates to longer waits in emergency departments, where they receive no treatment for days - and sometimes weeks - while social workers try to chase down open spots in psychiatric wards, doctors said."

Here’s a bunch of evidence for the "safety" of amphetamine use - if they are legal, that is.  If they are illegal, they are very dangerous. Interesting, since they all do exactly the same thing.

1/10/12.   Psychotic Symptoms More Likely Among Meth Addicts. MedPage Today (1/10, Phend) reports, "Methamphetamine use makes hallucinations and other psychotic symptoms substantially more likely among addicts, particularly for those abusing other substances," according to a 278-patient study published online Jan. 9 in JAMA Psychiatry. "The odds of psychotic symptoms were 5.3-fold higher during periods of meth use (P<0.001)," researchers reported. "That risk was dose-dependent and further doubled by frequent marijuana or alcohol use," the study found.

2/4/13.  Addictive Potential Of AD/HD Medicines Examined. On its front page, the New York Times (2/3, A1, Schwarz, Subscription Publication) reported that medications like Adderall (amphetamine, dextroamphetamine mixed salts) "can markedly improve the lives of children and others with" attention-deficit/hyperactivity "disorder [AD/HD]. But the tunnel-like focus the medicines provide has led growing numbers of teenagers and young adults to fake symptoms to obtain steady prescriptions for highly addictive medications that carry serious psychological dangers." Some doctors "skip established diagnostic procedures, renew prescriptions reflexively and spend too little time with patients to accurately monitor side effects." While "very few people who misuse stimulants devolve into psychotic or suicidal addicts...AD/HD practices can fail patients, particularly young adults."

1/10/13.  Among Meth Addicts, MedPage Today (1/10, Phend) reports, "Methamphetamine use makes hallucinations and other psychotic symptoms substantially more likely among addicts, particularly for those abusing other substances," according to a 278-patient study published online Jan. 9 in JAMA Psychiatry. "The odds of psychotic symptoms were 5.3-fold higher during periods of meth use (P<0.001)," researchers reported. "That risk was dose-dependent and further doubled by frequent marijuana or alcohol use," the study found.

1/11/13.  Dose-Dependent Relationship Found Between Meth Use and Psychosis Symptoms.  There appears to be a large dose-dependent increase in the occurrence of psychotic symptoms during periods of methamphetamine use, according to a study published online in JAMA Psychiatry. Australian researchers found a 5-fold increase in the likelihood of psychotic symptoms during periods of methamphetamine use compared with periods of no use. The increase was strongly dose-dependent: individuals who had used methamphetamine 16 or more days in the prior month were significantly more likely to experience psychotic symptoms than those who had used the drug 15 days or less.  The researchers looked at 278 participants aged 16 or older who met DSM-IV criteria for methamphetamine dependence but did not meet DSM-IV criteria for lifetime schizophrenia or mania. The main outcome measures were clinically significant psychotic symptoms in the prior month, defined as a score of 4 or more on any of the brief psychiatric rating scale items of suspiciousness, hallucinations, or unusual thought content.  “Although psychotic symptoms appeared to be largely circumscribed to periods of methamphetamine use, the long-term effect of methamphetamine use on a person’s vulnerability to psychosis needs to be better understood,” the researchers said.  For more information about the mental health effects of methamphetamine see Psychiatric News here.

1/28/13. Report: AD/HD Medication-Related Emergency Room Visits Up Sharply. The Los Angeles Times (1/25, Healy) reported in its "Booster Shots" health blog that a study found that between 2005 and 2010, "ADHD medication-related emergency room visits have more than doubled - from 13,379 in 2005 to 31,244 in 2010," with the increase being "particularly pronounced in those over 18." The data was "reported Thursday in an issue of the DAWN (Drug Abuse Warning Network) Report, published by the Substance Abuse and Mental Health Services Administration, an office of the National Institutes of Health." About half of the "stimulant-related emergency department visits --15,585 in 2010 - were for 'non-medical' use of ADHD medication: They were to treat stimulant-related effects in patients who either had not been diagnosed with ADHD and prescribed the drugs or in patients who were not taking the medication as prescribed."  HealthDay (1/26, Preidt) adds SAMHSA administrator Pamela Hyde said in an agency news release, "ADHD medications, when properly prescribed and used, can be of enormous benefit to those suffering from ADHD, but like any other medication they can pose serious risks - particularly when they are misused." Cases for adults "rose from about 2,100 to 8,100 among those aged 18 to 25, from about 1,750 to 6,100 among those aged 26 to 34 and from roughly 2,500 to nearly 8,000 among those over 35, during the time period." The study found that the gap between males and females in the number of ER visits related to nonmedical use of ADHD drugs was narrowing. "In 2005, the numbers were about 3,800 for males and about 1,400 for females. In 2011, numbers reached 8,650 for males and about 6,900 for females." Medscape (1/26, Brauser) also covered the story.

2/8/13.  Maternal Depression, Domestic Violence May Raise Kids' Risk For AD/HD. HealthDay (2/8, Mann) reports, "Preschoolers whose parents report depression and intimate partner violence may be more likely to develop attention-deficit/hyperactivity disorder (AD/HD) by the age of six." Furthermore, "young children with depressed moms may be more likely to receive prescription drugs to treat behavioral and mental health issues down the road," according to a study published online Feb. 4 in the journal JAMA Pediatrics. The study "included more than 2,400 children who were three years old" and their parents who answered questionnaires regarding domestic violence and personal depression history.

So you mean some of the kids who are diagnosed with ADHD are in reality just reacting to chaotic families and not to video games? And they are not diseased?

2/12/13.  Violent Video Game Proliferation Has Not Coincided With Spikes In Youth Violent Crime. On the front of its Science Times section, the New York Times (2/12, D1, Carey, Subscription Publication) reports, "In surveys about 80 percent of high school-age boys say they play video games, most of which are thought to be violent, and perhaps a third to a half of those players have had a habit of 10 hours a week or more." The Times notes, however, that "the proliferation of violent video games has not coincided with spikes in youth violent crime." In fact, "the number of violent youth offenders fell by more than half between 1994 and 2010, to 224 per 100,000 population, according to government statistics, while video game sales have more than doubled since 1996." The article describes contradictory research into how media violence and video games may affect behavior.

1/31/12.  Non-Drug Treatments May Not Reduce Key Symptoms Of AD/HD. MedPage Today (1/31, Bankhead) reports that "nondrug treatments for attention deficit/hyperactivity disorder have limited evidence of efficacy and their use for core symptoms is not supported, a European guideline committee concluded." While "uncontrolled clinical evaluations produced positive results for a variety of dietary and psychological interventions," these "significant benefits disappeared in 'probably blinded' assessments, except for free fatty acid (FFA) supplementation and avoidance of artificial food color, according to" an article from the European ADHD Guideline Group published online January 30 in the American Journal of Psychiatry. MedPage Today adds, "Meta-analyses and systematic reviews have supported the efficacy of nonpharmacologic interventions in ADHD, but inclusion of nonrandomized trials and non-ADHD patients and outcome measures has complicated attempts to evaluate the interventions' effects on ADHD core symptoms, the committee members wrote."  HealthDay (1/31, Gray) reports that the "multinational team of experts" involved in the study "identified no positive effects from psychological treatments including mind exercises (cognitive training), neurofeedback and behavioral training (positive reinforcement). And the researchers discovered only small benefits associated with dietary treatments: supplementation with omega-3 and omega-6 free fatty acids, and elimination of artificial food coloring." HealthDay notes that "according to the American Psychiatric Association, between 3 percent and 7 percent of U.S. children have" ADHD. Medscape (1/31, Cassels) also covers the story.

Notice how exactly no non-drug treatments that  involve intervention with dysfunctional families, or even talk therapies, were included in this study. The psychological treatments they do mention are of course totally inadequate and off the mark, yet the authors broadly conclude that no non-drug treatments are likely to be effective. 

This is what we refer to in logic circles as a Straw Man Argument. It is probably also true that if the authors did  a similar studies on drug therapy, and the drug used was penicillin, that "drugs" would be shown to be ineffective as well.

And finally, of course as we all know there is no evidence of a push by big Pharma to increase the number of ADHD diagnoses dramatically.

1/22/13.  ADHD Diagnoses in California Health Plan Jump 24 Percent in 10 Years. Rates of diagnosis of ADHD among children in a large California health plan jumped 24 percent from 2001 to 2010, according to a report this week in JAMA-Pediatrics. In the study, researchers at Kaiser Permanente Southern California (KPSC) examined medical records for all children who received care at KPSC from January 2, 2001, through December 31, 2010. Records for 842,830 children were studied. The main outcome measure was incidence of physician-diagnosed ADHD in children aged 5 to 11.  The researchers found that rates of ADHD diagnosis were 2.5% in 2001 and 3.1% in 2010. They also found that the rate increased most among whites, followed by blacks and Hispanics, and that children living in high-income households were at increased risk of diagnosis compared with peers in lower-income households. The increase in ADHD diagnosis among blacks was largely driven by an increase in diagnoses among girls.  “The findings of this study suggest increasing trends in the clinical diagnosis of ADHD among children in the health plan,” the researchers said. “We also observed disproportionately high ADHD diagnosis rates among white children and notable increases in rates among black girls over time.”


Readers of this blog know that it can be extremely difficult determining which neuroscientific findings represent evidence of brain pathology and which do no. However, in the case of schizophrenia, the evidence of a miswired brain keeps on piling up. To me, this evidence is especially convincing since many findings - like oddly abnormal eye movements -  involve brain areas that have nothing to do with hallucinations, delusions, or other symptoms of the disorder, and therefore would not be better accounted for by normal environmental conditioning of brain pathways through neural plasticity. And many of these phenomena are found in patients who have never taken an antipsychotic medication. (As if it weren’t already blatantly obvious that schizophrenia is a real disease to anyone who has spent significant time working with patients over time in a state mental hospital). 

Can a new eye test detect schizophrenia?  A mathematical model that assesses eye movements known to be abnormal in individuals with schizophrenia appears to discriminate schizophrenia cases from controls with near-perfect accuracy. The lead scientist was philip benson, ph.d., of the university of aberdeen in scotland, and study findings were published in biological psychiatry. "this is a very interesting study," l. Elliot hong, m.d., a professor of psychiatry at the university of maryland and a schizophrenia expert, commented to psychiatric news. "[however] the important next steps are [determining] whether these measures are specific only to schizophrenia or whether they can also separate different psychiatric diagnoses...." benson agreed. "we already know that the model can distinguish cases diagnosed with bipolar disorder [from those diagnosed with schizophrenia] with around 95 percent accuracy. We have preliminary data suggesting that major depressive disorder can also be distinguished [from schizophrenia], which is a tremendously exciting finding."

10/12/12.  Meta-Analysis: Brain Volume Reduced In Patients With SchizophreniaMedwire (10/12, Cowen) reports, "Medicated and antipsychotic-naïve [meaning that the patients have never taken these drugs] patients with schizophrenia show significant reductions in brain volume," according to a study published online Oct. 5 in the Schizophrenia Bulletin. "In a meta-analysis of data from 317 published studies," researchers "found that intracranial and total brain volumes were significantly reduced in schizophrenia patients compared with controls, after accounting for age, gender, duration of illness, and other variables."

12/13/12.  Small Study: Relatives Of Patients With Schizophrenia May Show Cortical Thinning. Medwire (12/13, Cowen) reports, "Patients with schizophrenia and their unaffected relatives show significant cortical thinning compared with mentally healthy individuals without such a family history," according to a study published in the journal Cerebral Cortex. Researchers arrived at that conclusion after having "used magnetic resonance imaging to assess cortical thickness in 25 patients with schizophrenia, 29 of their first-degree relatives, and 37 age-, gender-, and parental education-matched mentally healthy controls without a family history of schizophrenia."

Research Models

2/12/13.  Researchers: Mice May Be Poor Models For Studying Some Human Ailments. The New York Times (2/12, A19, Kolata, Subscription Publication) reports, "For decades, mice have been the species of choice in the study of human diseases." However, in a study published in the Proceedings of the National Academy of Sciences, "researchers report evidence that the mouse model has been totally misleading for at least three major killers - sepsis, burns and trauma." The study's "authors said" the findings "raise troubling questions about diseases like the ones in the study that involve the immune system, including cancer and heart disease."  Bloomberg News (2/12, Lopatto) reports that some "explanations for the discrepancy may be that the model mice are too inbred to be useful, or that the modeling doesn't reflect the illnesses experienced by trauma patients." Moreover, "the difference in recovery time between mice and people may play a role, and clinical care, such as drugs, surgery and life support, may further attenuate similarities."

Or it could be that rats do not have much capacity for reasoning. Rats who are turned into alcohol addicts, after all, never hide the bottles.

How Dysfunctional Families Spur Mental Disorders

2/14/13.  "Helicopter" Parents May Make Their College-Aged Kids Depressed. Reuters (2/14, Goldsmith) reports that according to a study published in Springer's Journal of Child and Family Studies, helicopter parents who overcontrol aspects of their university student children's lives may be causing the young people to become depressed. Researchers arrived at this conclusion after analyzing survey results taken from 297 undergraduates from US institutes of higher education.

What a shock!!

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