I have frequently blogged in this venue about
the efficacy of antidepressants in “depression.” I have pointed out that “depression” has a
wide variety of different meanings, and that there are also several different
syndromes of depressive disorders in the diagnostic manual, the DSM. While there is considerable overlap in the
symptoms of the various syndromes, some are far more likely to respond, and
respond dramatically, to antidepressant medication than others.
I have also ranted against physicians who use “symptom
checklists” or other self-report “tests” to make a diagnosis of depression,
rather than use an extensive clinical interview. The tests often say very little about whether
a symptom a patient complains of is clinically significant for a certain
diagnostic syndrome or not. Aside from
not looking at the psychosocial context in which the symptom occurs, the tests
usually say very little about three important qualities of clinically
significant symptoms – their pervasiveness, persistence, and whether or not
they are pathological. They also do not
clearly show whether the symptoms all cluster together at the same times.
As I have pointed out several times, in order to
make sure the patient is giving the doc an accurate and complete picture of their
mood state, a good doctor must often ask one or even several follow up
questions whenever a patient says “yes” or “no” in answer to a question about
the presence of a symptom.
But how about a potential patient? How does a non-professional know whether or not to
even consult a physician about their mood state? Why not just ignore it and see if it goes
away? Alternately, why not just go to a
psychotherapist and handle it with psychotherapy alone?
That’s a very important question. A similar question has recently been widely featured
in the media in response to a proposed change in the DSM. How does a patient or a doctor know when
normal grief after the death of a loved one morphs into a clinical depression that
would respond to medication? The argument
has mostly been about how long a doctor should wait after such a death before
making a diagnosis of clinical depression, (major depressive
disorder).
While it is good that a doctor should not be overly
hasty about making a diagnosis in this situation, in some genetically-prone
individual, a stress of that severity can indeed trigger a major depressive
disorder in a relatively short period of time.
Should that patient have to wait to be relieved of his or her
suffering? Certainly, any proposed “waiting
period” specified in the DSM would have to be somewhat arbitrary.
To help patients figure out who to consult and
when to consult a physician, a new self-report instrument is available that is
significantly superior to the usual ones.
It is called the Post-Bereavement
Phenomenology Inventory. It is meant to distinguish normal grief from major
depression, but potentially it could also be used to distinguish major depression (likely
to respond to meds) from another depressive syndrome, dysthymia (much less
likely to respond to meds).
It was meant for physicians and not for patients to review for themselves, but even though it is better than most self-report instruments, IMO
it should still not be used in place of a complete and wide-ranging clinical
interview. Context, prior history of
major depressive disorders, family history of depression, and a whole host of
factors need to also be considered.
But as a screening tool for patients, I think it
might be helpful. It uses a strategy
called prototype matching. This strategy focuses on the difference between depressive syndromes
rather than the similarities. The questions contain different descriptions of how each depressive symptom would present itself
in classic cases of the two syndromes, and asks the patient, “[Which of the two
descriptions] better describes how you have been feeling, thinking, or behaving
for the past one to two months?”
Here it is.
I hope this will help potential patients decide whom to consult. The first descriptions in each question are
of the symptom presentation seen in major depression, while the second are of depressive
symptoms that are less likely to respond to medication. Of course, this is hardly foolproof, but
generally the more you answer the questions one way or the other, the more
likely you are to be experiencing one syndrome or the other.
If someone's depression seems to conform mostly to the first prototype rather than the second, there are certain things that people often say to them that are both inappropriate and counterproductive. An excellent list of such things can be found at http://www.medicalbillingandcoding.org/blog/11-things-you-should-never-say-to-someone-with-depression/
1.
I am filled with
despair nearly all the time, and I almost always feel hopeless about the
future.
versus
I feel sadness a lot of the time, but I
believe that eventually, things will get better.
2.
My sadness or depressed mood is nearly
constant, and it isn't improved by any positive events, activities, or people.
versus
My sadness or depressed mood usually comes in
"waves" or "pangs;' and there are events, activities, or people
who help me feel better.
3.
When I am reminded of my loss (of a loved one,
friend, job, etc), I feel nothing but pain, bitterness, or bad memories.
versus
When I am reminded of my loss (of a loved one, friend,
job, etc), I often feel intense grief or have painful memories, but sometimes I
have good thoughts and pleasant memories.
4.
I will probably never get back to feeling like
my "old self" again.
versus
Things are really
tough now, but I'm hopeful that with time I will feel more like my "old
self.”
5.
I feel like a worthless person who has done
mostly bad things in life, and has let my friends, family, and loved ones down.
versus
I feel like I'm
basically a good person and that, in general, I have done my best for my
friends, family, and loved ones.
6.
All I can think about lately is me and how
miserable I feel; I hardly think about friends, family, or loved ones, except
to blame myself for some failing.
versus
Even though I'm
less social and outgoing since my loss, I still think a lot about friends,
family, and loved ones, often with good feelings about them.
7.
When friends or family call or visit and try
to cheer me up, I don't feel anything or I may feel even worse.
versus
When friends or family call or visit and try to cheer me
up, I usually "perk up" for a while and enjoy the social contact.
8.
I often have persistent thoughts or impulses
about ending my life, and I often think I'd be better off dead.
versus
I sometimes feel like a part of me has been lost and I
wish I could be reunited with the person or part of my life I am missing, but I
still think life is worth living.
9.
Almost nothing that I used to like doing
(reading, listening to music, sports, hobbies, etc) is of any comfort or consolation
to me anymore.
versus
The things that I have always liked doing (reading,
listening to music, sports, hobbies,etc) give me some comfort and consolation,
at least temporarily.
10. I feel "slowed down" inside, like my body and mind are stuck or
frozen, and like time itself is standing still.
versus
My concentration isn't as good as usual, but my body and
mind aren't slowed down, and time passes in the usual way.