The continuing stoow-ry of psychiatric research that has gone to the dogs
In my last book, How Dysfunctional Families Spur Mental Disorders, I discussed my theory that the drug companies of Big Pharma seem to go out of their way to demonize entire classes of drugs once they are mostly available as generics, so that practitioners will use their new brand named drugs instead - regardless of whether or not they are as effective or more dangerous. This happened with benzodiazepines, which now seem to be referred to absurdly as the most addictive and dangerous substances on the planet and full of "side effects" - which don’t actually occur in the real world in the vast, vast majority of patients who take them.
Now comes another
bogus study that purports to show the same thing as the Sachs study. According to an article in Medscape on May 20, 2013, “Investigators at Brown
University in Providence, Rhode Island, found there was no difference in
hospital readmission rates among patients who received antidepressants and
those who did not." Since the authors are strongly implying that the patients
had to be readmitted because their antidepressant was not working, this is
taken to mean that antidepressants don’t work in bipolar depression.
In my last book, How Dysfunctional Families Spur Mental Disorders, I discussed my theory that the drug companies of Big Pharma seem to go out of their way to demonize entire classes of drugs once they are mostly available as generics, so that practitioners will use their new brand named drugs instead - regardless of whether or not they are as effective or more dangerous. This happened with benzodiazepines, which now seem to be referred to absurdly as the most addictive and dangerous substances on the planet and full of "side effects" - which don’t actually occur in the real world in the vast, vast majority of patients who take them.
(BTW. demonizing generics
does not just occur in psychiatry. One patient told me that a relative was
given an anticoagulant that was more dangerous than generic Coumadin because, according to the doctor, “That’s
what the drug companies want us to do”).
I wrote that I
suspected that the same strategy is now being applied to antidepressants. Most
of them have gone generic. (The ones that haven’t yet are Viibryd, Cymbalta, and
Prestique. Although no more effective that the generics, it amazes me how
many doctors seem to use them as first line drugs). All of sudden we are being
deluged by both news and journal articles questioning whether the drugs are
effective. I have written in previous posts on this blog that placebo
response rates for antidepressants have gone up significantly every decade,
indicating that the patient population being used in the studies is changing.
Specifically,
so-called contract research organizations are being given financial incentives for
finding patients that they can diagnose with major depression, and potential patients are given financial incentives for exaggerating their symptoms so they can get
paid for being research subjects. So the studies are using patients that
don’t really have the diagnosis they are supposedly being treated for. No
wonder they have a high placebo response rate. This higher rate makes the
advantage of the drug over placebo in these studies seem highly questionable.
A similar process is
happening in doctors’ offices all over the country. Diagnostic interviews are getting sloppier and
more slipshod all the time. A new study published by Psychotherapy and Psychosomatics, according to the June 2013 issue
of the newspaper Clinical
Psychiatric News, seems to be highly consistent with this idea. The authors ascertained whether patients who were identified by their doctors as
depressed actually met DSM criteria for major depressive disorder. Results with
5639 participants showed that only 38.4% of these patients actually met the criteria!
This phenomenon has led
to a couple of ironic developments. First, the rabidly anti-psychiatry zealots
point to the bad studies as “proof” that psychiatric meds are a hoax, while of
course completely ignoring all the earlier studies that show that antidepressants are
highly effective. The more severe the depression, the more likely a patient is
to respond to them.
Second, people both
inside and outside of the psychiatric profession unfairly rail against the diagnostic
manual, the DSM, for not having valid criteria, when the real problem is in many cases that many doctors are not applying the
criteria to the patients in making "diagnoses!"
Then there is the
matter of the use of antidepressants in the depressed phase of bipolar
disorder. Of course, as I have said many times, the duration and
pervasiveness criteria for bipolar episodes, either manic or depressed, are more and more often ignored, which calls into question whether the diagnoses in studies are even
correct.
Anyway, in my book I
brought up a study by Sachs and others in the New
England Journal of Medicine, the most prestigious journal in all of
medicine, that purported to show that antidepressants work worse than placebo
in this population. I showed how the authors of the study used a sample
of patients that were especially treatment resistant, having already failed a
trial of at least one previous antidepressant, but did not acknowledge this
fact in the paper at all. I was even able to question the author through
a third party, since my e-mails directly to Sachs were ignored, and he steadfastly refused
to answer the question, “What percentage of your sample had failed a previous
antidepressant?”
That antidepressants do not work in bipolar depression
is a flat out lie. Psychiatrists like myself have been using
antidepressants successfully in bipolar patients for thirty five years. Of
course, true bipolar patients need to be
on a mood-stabilizer first, preferably lithium, so they don't switch from depression
into mania.
So what’s wrong with this study? Well, just about everything. First of all, we
do not know if these patients were correctly diagnosed for the reasons
discussed above. Another huge problem: all over the country, hospitalized patients
with borderline personality disorder are being misdiagnosed with bipolar disorder because
of the “everything is bipolar" craze, coupled with the fact that insurance companies will often not pay for hospital stays if the patients are given the correct, "lesser" diagnosis!
The subjects in this survey were undoubtedly a very
mixed lot. The study did not address whether the patients even took their
medication after they were discharged. Non-compliance rates for all
medications are very high according to every available study that has looked at
this issue. Also, we do not know what
percentage of these patients may have fallen into the “treatment resistant”
category described above. Most depressed
patients are treated as outpatients, not inpatients, so the ones that are
hospitalized have often failed a trial of outpatient medication.
Adding to this is the fact that antidepressants do not
work for at least a couple of weeks, while managed care insurance companies will
not pay for that length of stay. Therefore, patients on antidepressants are often
discharged before the doctor knows whether a particular antidepressant even worked. Often patients do not respond to one
antidepressant but do respond to a different one.
Hence, discharge and re-hospitalization rates tell us pretty much nothing
about the effectiveness of antidepressants in the depressed phase of bipolar
disorder.
The International Society for Bipolar Disorders (ISBD) Task
Force recently released its long-anticipated recommendations on antidepressant use
in bipolar disorders. "The
take-home message is that antidepressants have a questionable benefit-risk and
should only be used in certain cases in bipolar disorder," said Dr. Eduard
Vieta, who presented the recommendations on behalf of the ISBD Task Force, in
an interview.
Eduard Vieta |
"First,
they shouldn't be used in mania or in mixed episodes, they should only be used
in bipolar depression in patients with a history of a good response in the past
to antidepressants and no history of rapid cycling or switches into mania right
away," he said.
“Further,
antidepressants should not be used in patients with bipolar disease with mixed
features during a depressive episode or some manic symptoms during
depression.”
The recommendations said that antidepressants should not be used as
monotherapy for bipolar depression, or in rapid cycling.
I have a few reactions to this.
1. Duh! We've known about the risks
of using antidepressants alone in Bipolar I patients since the sixties. We've also
known that they are perfectly safe and highly effective if a bipolar patient in
a depressive episode is on an effective mood stabilizer, preferably Lithium.
The way that the recommendation is
made, however, is highly misleading. Antidepressants indeed should not be used as "monotherapy," but not because they are ineffective for depression. It may sound to
some doctors that this is what is being said. The real reason is because patients
need to be on a second drug to prevent switching into mania.
2. What are they defining as
"rapid cycling?" A majority of patients who get this diagnosis
nowadays are not bipolar at all, but have anxiety disorders, mixed anxiety and
dysthymia, and/or personality disorders - otherwise known as 'crappy childhood
syndrome." A lot of drugs can
cause these folks more harm than good if improperly used! Why single
out antidepressants?
3.
How are we supposed to know if a patient will respond to an
antidepressant in cases of patients who have never taken one, if we are not supposed to use them unless the
patient already has a history of responding to them? That would be quite a
trick! Additionally, a history of a switch
into mania is not a contraindication for antidepressants unless this history
took place when the patient had been adequately medicated with a mood
stabilizer. If they switched when not
taking one, that fact would be completely irrelevant. Even the Sachs study
showed patients on a mood stabilizer don’t switch into mania with antidepressants.
4. As for so-called mixed episodes,
they are in reality manic episodes, with the difference being that the
patient feels really uncomfortable instead of the more typical euphoria. Since they are in a manic state and not a
depressed one, of course antidepressants should not be used!